INRIX data shows that the M5 will be worst hit between J4 and J1, with travel times increasing from 21 minutes to 1hr 21 minutes.
The M1 is predicted to be badly affected from J22 to J25 with journey times increasing from a typical 16 minutes to 62 minutes on Saturday.
Highways England is lifting and completing more than 300 miles of roadworks on motorways and major A roads from Friday morning to help drivers get to their destinations more easily.
Rainfall has been predicted for Sunday
RAC traffic spokesman Rod Dennis said: "While the late August bank holiday is not typically one of the busiest on the roads due to it falling in the middle of the school holidays when people are already away, either in the UK or abroad, it still has huge potential to bring gridlock to major roads, especially if we were to see the sun make a welcome comeback.
"There are plenty of known hotspots on the motorway network but probably the single biggest one in the summer months is the Almondsbury interchange at Bristol, right by the RAC building, where the M5 and the M4 meet.
"As tens of thousands of drivers head for Devon and Cornwall the coming-together of traffic leads to regular tailbacks every Friday afternoon."
Train passengers hoping to travel between London and major cities including Manchester and Birmingham will be affected by the closure of Euston station.
For some parts of the UK, there is a #bankholiday in store. Here is a quick snapshot of the weather you can expect #soggysandwich pic.twitter.com/DLgbvRk2YJ
— Met Office (@metoffice) August 24, 2018
Virgin Trains stated that "due to extensive engineering works on the west coast route" the station will run no services between Saturday 25 and Monday 27 August.
The firm adds: "We highly recommend that you avoid travelling on these dates unless absolutely necessary."
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