Growth Hormone-Releasing Hormone has been synthetically modified and tetrasubstituted in CJC-1295 (GHRH1-29). The core moiety of CJC-1295 peptide has four amino acids substituted, increasing its resistance to cleavage by proteolytic enzymes.
This compound has a chemical formula of C152H252N44O42 and comprises 30 amino acids. Its molecular weight is 3368.7 Daltons. Drug Affinity Complex (DAC) increases the half-life and duration of effect of CJC-1295 in animal test subjects by binding to serum albumin a.
CJC-1295's mechanism of action with DAC
In animal studies, CJC-1295 peptide was shown to interact with Growth Hormone (GH), Insulin-like Growth Factor 1 (IGF-1), and Dipeptidyl Amino Peptidase IV (DPP-IV).
DPP-IV functions include signal transmission, apoptosis or programmed cell death, and control of the innate immune system. It also directly impacts the half-life of Growth Hormone (GH), which is reduced to just under seven minutes by this treatment.
CJC-1295 has reduced DPP-IV enzyme production. GH and IGF-1's half-lives are extended and persist longer than seven days after injection on animal test participants due to this feedback loop.
Effects of CJC-1295
The CJC-1295 peptide increases the half-life of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1), which raises the processes involving these hormones, is explained by its mode of action. Effects include, but are not limited to:
Protein synthesis is boosted. It's been discovered that CJC-1295 increases the rate of protein synthesis in animals by prolonging the half-life of growth hormone and insulin growth factor 1. As a consequence, their muscles get more extensive and heavier with time.
Bone Density Increased. Bone density may be improved by increasing the amount of protein synthesis in the body. Higher mineral matter per square centimeter in animal bones following CJC-1295 administration has been shown.
Reduction in Body Fat Percentage. Lipolysis, the process by which fat is broken down and removed from the body, may be aided by CJC-1295's effects on DPP-IV and GHRH. Increased lipolysis has been shown to reduce total body fat in test individuals.
Enhances the quality of one's sleep. There is no quantifiable method for measuring animal subjects' quality of sleep. Still, this impact is supported by the theory that an increased quantity of deep sleep compensates for the enhanced rate of protein synthesis.
CJC-1295 sans DAC vs. CJC-1295 w/DAC
It's critical to understand the impacts of peptides and how various substances might modify their characteristics before purchasing them. Peptide buyers have a wide range of alternatives to choose from on the market.
However, even though unaltered CJC-1295 exhibits the characteristics above, adding DAC is thought to enhance the overall impact. According to animal studies, CJC-1295 with DAC has better effects on protein synthesis, shorter recovery times, increased bone density, and more excellent muscular development than CJC-1295 without DAC. If you are a licensed professional, you can buy online CJC-1295 DAC to further your research and the field of information available on the topic.
Dosage of CJC 1295 DAC
It is recommended to use 2mg of CJC-1295 and 2ml of water for injectable sterilization as a starting point. Dilution is preferable, and germicidal water is ideal.
Recommendation: 30-60 g per 1 kg of body weight per week is the suggested dose for CJC 1295 DAC. Ideally, divide the dosage into two injections over the week since the fifth day following administration tends to be less effective. A weekly dose of 60 mg per kilogram of body weight is ineffective.
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